Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.

 

Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.

Show full item record

Title: Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.
Author: Tian, Jide; Dang, Hoa; von Boehmer, Harald; Jaeckel, Elmar; Kaufman, Daniel L
Abstract: To study how tolerance to GAD65 affects the development of autoimmunity to other beta-cell autoantigens (beta-CAAs) in GAD65-transgenic (GAD-tg) NOD mice.
Citation: Diabetes. 2009 Dec;58(12): 2843-50. EPub 2009 Sep 09
PMC: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=19741165

This item appears in the following Collection(s)

Show full item record